Level 8 DiseaseLockjaw

Stage 0: The target recovers from the disease.
Stage 1: Initial Effect: The target takes a -2 penalty to Reflex.
Stage 2: Target takes a -2 penalty to Reflex. Each time the target fails to improve from this step, the target takes an additional -2 penalty.
Stage 3: Final State: When the target’s Reflex reaches 0, the victim is permanently immobilized and can’t take actions. The target can be cured only by a Remove Affliction ritual or any effect that can end the petrified condition.
Check: At the end of each extended rest, the target makes an Endurance check if it is at stage 1 or 2.
24 or lower: The stage of the disease increases by one.
25-28: No Change
29 or higher: The stage of the disease decreases by one.

Published in Dungeon Magazine 178.