Level 6 DiseaseSlavering Canker

Stage 0: The target recovers from the disease.
Stage 1: Initial Effect: The target takes a -1 penalty to attack rolls and damage rolls.
Stage 2: The target takes a -2 penalty to attack rolls and damage rolls, and regains 5 fewer than the normal number of hit points from healing effects.
Stage 3: Final State: The target is weakened, and must rest for twice as long as normal to gain the benefit of a short rest or an extended rest.
Check: At the end of each extended rest, the target makes an Endurance check if it is at stage 1 or 2.
10 or lower: The stage of the disease increases by one.
11-14: No Change
15 or higher: The stage of the disease decreases by one.

Published in Monster Manual 2, page(s) 126.