Level 17 DiseaseSpider Queen's Curse

The infected creature feels strangely invigorated as its body becomes host to thousands of tiny spider eggs.

Stage 0: The target recovers from the disease.
Stage 1: While affected by this stage, the target gains a +1 bonus to Fortitude, Reflex, and Will. Whenever the target spends a healing surge, it regains 2d6 extra hit points.
Stage 2: While affected by this stage, the target keeps the +1 bonus to Fortitude, Reflex, and Will, but takes a -2 penalty to Endurance checks made to recover from this disease. Whenever the target spends a healing surge, it regains 3d6 extra hit points.
Stage 3: The target dies. A spider swarm (described in Monster Vault) erupts from the target’s corpse.
Check: At the end of each extended rest, the target makes an Endurance check if it is at stage 1 or 2.
15 or lower: The stage of the disease increases by one.
16-22: No Change
23 or higher: The stage of the disease decreases by one.

Published in Monster Vault: Threats to the Nentir Vale, page(s) 69.